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KMID : 1188320150090050641
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Gut and Liver
2015 Volume.9 No. 5 p.641 ~ p.648
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The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test
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Kim Yong-Cheol
Kim Jeong-Ho
Cheung Dae-Young
Kim Tae-Ho
Jun Eun-Jung
Oh Jung-Whan
Kim Chang-Whan
Chung Woo-Chul
Kim Byung-Wook
Kim Sung-Soo
Kim Jin-Il
Park Soo-Heon
Kim Jae-Kwang
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Abstract
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Background/Aims:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions.
Methods:Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospitals in the capital province of Korea. The iM2-PK value was compared with the immunochromatographic fecal occult blood test (iFOBT) and fecal tumor M2-PK enzyme-linked immunosorbent assay (ELISA).
Results:A total of 323 subjects were enrolled. The sensitivity of iM2-PK for CRC was 92.8%, which was superior to iFOBT (47.5%, p<0.0001). For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001). Compared with M2-PK ELISA, iM2-PK exhibited significantly enhanced sensitivity for CRC (97.5% vs 80.0%, p=0.0289). The sensitivity of iM2-PK was higher in advanced stages of CRC compared with cancers confined to the mucosa and submucosa (p<0.05). However, lymph node metastasis had no influence on the sensitivity of iM2-PK.
Conclusions:The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT. Given its rapid results and convenience, CRC screening using iM2-PK is promising.
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KEYWORD
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Colorectal neoplasms, Fecal occult blood test, Mass screening, Tumor M2 pyruvate kinase
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